diff --git a/src/app-layer.c b/src/app-layer.c
index e5efcdf361..448cdc1066 100644
--- a/src/app-layer.c
+++ b/src/app-layer.c
@@ -460,6 +460,8 @@ static int TCPProtoDetect(ThreadVars *tv, TcpReassemblyThreadCtx *ra_ctx,
                 SCLogDebug("reversing flow after proto detect told us so");
                 PacketSwap(p);
                 FlowSwap(f);
+                // Will reset signature groups in DetectRunSetup
+                f->de_ctx_version = UINT32_MAX;
                 SWAP_FLAGS(flags, STREAM_TOSERVER, STREAM_TOCLIENT);
                 if (*stream == &ssn->client) {
                     *stream = &ssn->server;