diff --git a/src/duckstation-qt/mainwindow.cpp b/src/duckstation-qt/mainwindow.cpp
index 65913bf3a..2aafb3e29 100644
--- a/src/duckstation-qt/mainwindow.cpp
+++ b/src/duckstation-qt/mainwindow.cpp
@@ -272,6 +272,11 @@ void MainWindow::onChangeDiscFromGameListActionTriggered()
   switchToGameListView();
 }
 
+void MainWindow::onRemoveDiscActionTriggered()
+{
+  m_host_interface->changeDisc(QString());
+}
+
 static void OpenURL(QWidget* parent, const QUrl& qurl)
 {
   if (!QDesktopServices::openUrl(qurl))
@@ -503,6 +508,7 @@ void MainWindow::connectSignals()
   connect(m_ui.actionChangeDiscFromFile, &QAction::triggered, this, &MainWindow::onChangeDiscFromFileActionTriggered);
   connect(m_ui.actionChangeDiscFromGameList, &QAction::triggered, this,
           &MainWindow::onChangeDiscFromGameListActionTriggered);
+  connect(m_ui.actionRemoveDisc, &QAction::triggered, this, &MainWindow::onRemoveDiscActionTriggered);
   connect(m_ui.actionAddGameDirectory, &QAction::triggered,
           [this]() { getSettingsDialog()->getGameListSettingsWidget()->addSearchDirectory(this); });
   connect(m_ui.actionPowerOff, &QAction::triggered, m_host_interface, &QtHostInterface::powerOffSystem);
diff --git a/src/duckstation-qt/mainwindow.h b/src/duckstation-qt/mainwindow.h
index 6701d6121..49a15c584 100644
--- a/src/duckstation-qt/mainwindow.h
+++ b/src/duckstation-qt/mainwindow.h
@@ -45,6 +45,7 @@ private Q_SLOTS:
   void onStartBIOSActionTriggered();
   void onChangeDiscFromFileActionTriggered();
   void onChangeDiscFromGameListActionTriggered();
+  void onRemoveDiscActionTriggered();
   void onGitHubRepositoryActionTriggered();
   void onIssueTrackerActionTriggered();
   void onDiscordServerActionTriggered();
diff --git a/src/duckstation-qt/mainwindow.ui b/src/duckstation-qt/mainwindow.ui
index 928182c17..ce4b3bbaa 100644
--- a/src/duckstation-qt/mainwindow.ui
+++ b/src/duckstation-qt/mainwindow.ui
@@ -47,6 +47,7 @@
      </property>
      <addaction name="actionChangeDiscFromFile"/>
      <addaction name="actionChangeDiscFromGameList"/>
+     <addaction name="actionRemoveDisc"/>
     </widget>
     <widget class="QMenu" name="menuLoadState">
      <property name="title">
@@ -399,6 +400,11 @@
     <string>From Game List...</string>
    </property>
   </action>
+  <action name="actionRemoveDisc">
+   <property name="text">
+    <string>Remove Disc</string>
+   </property>
+  </action>
   <action name="actionResume_State">
    <property name="text">
     <string>Resume State</string>
diff --git a/src/duckstation-qt/qthostinterface.cpp b/src/duckstation-qt/qthostinterface.cpp
index ad0090476..ed7b6705d 100644
--- a/src/duckstation-qt/qthostinterface.cpp
+++ b/src/duckstation-qt/qthostinterface.cpp
@@ -615,7 +615,10 @@ void QtHostInterface::changeDisc(const QString& new_disc_filename)
   if (!m_system)
     return;
 
-  m_system->InsertMedia(new_disc_filename.toStdString().c_str());
+  if (!new_disc_filename.isEmpty())
+    m_system->InsertMedia(new_disc_filename.toStdString().c_str());
+  else
+    m_system->RemoveMedia();
 }
 
 static QString FormatTimestampForSaveStateMenu(u64 timestamp)