diff --git a/src/core/bus.cpp b/src/core/bus.cpp
index c3c7e9f8a..bcdab1926 100644
--- a/src/core/bus.cpp
+++ b/src/core/bus.cpp
@@ -1609,23 +1609,21 @@ void Bus::EXP2WriteHandler(VirtualMemoryAddress address, u32 value)
   {
     DEV_LOG("BIOS POST2 status: {:02X}", value & UINT32_C(0x0F));
   }
-#if 0
-  // TODO: Put behind configuration variable
-  else if (offset == 0x81)
-  {
-    Log_WarningPrint("pcsx_debugbreak()");
-    Host::ReportErrorAsync("Error", "pcsx_debugbreak()");
-    System::PauseSystem(true);
-    CPU::ExitExecution();
-  }
-  else if (offset == 0x82)
+  else if (offset >= 0x81 && offset <= 0x82 && g_settings.pcsx_expansion_region_enable)
   {
-    Log_WarningFmt("pcsx_exit() with status 0x{:02X}", value & UINT32_C(0xFF));
-    Host::ReportErrorAsync("Error", fmt::format("pcsx_exit() with status 0x{:02X}", value & UINT32_C(0xFF)));
-    System::ShutdownSystem(false);
-    CPU::ExitExecution();
+    if (offset == 0x81)
+    {
+      WARNING_LOG("pcsx_debugbreak()");
+      System::PauseSystem(true);
+      CPU::ExitExecution();
+    }
+    else // if (offset == 0x82)
+    {
+      WARNING_LOG("pcsx_exit() with status 0x{:02X}", value & UINT32_C(0xFF));
+      System::ShutdownSystem(false);
+      CPU::ExitExecution();
+    }
   }
-#endif
   else
   {
     WARNING_LOG("EXP2 write: 0x{:08X} <- 0x{:08X}", address, value);
diff --git a/src/core/settings.cpp b/src/core/settings.cpp
index bc6574244..c3720580f 100644
--- a/src/core/settings.cpp
+++ b/src/core/settings.cpp
@@ -632,6 +632,8 @@ void Settings::Load(const SettingsInterface& si, const SettingsInterface& contro
   pcdrv_enable_writes = si.GetBoolValue("PCDrv", "EnableWrites", false);
   pcdrv_root = si.GetStringViewValue("PCDrv", "Root");
 
+  pcsx_expansion_region_enable = si.GetBoolValue("Debug", "PCSXExpansionRegion", false);
+
 #ifdef __ANDROID__
   // Android users are incredibly silly and don't understand that stretch is in the aspect ratio list...
   if (si.GetBoolValue("Display", "Stretch", false))
@@ -954,6 +956,8 @@ void Settings::Save(SettingsInterface& si, bool ignore_base) const
   si.SetBoolValue("PCDrv", "Enabled", pcdrv_enable);
   si.SetBoolValue("PCDrv", "EnableWrites", pcdrv_enable_writes);
   si.SetStringValue("PCDrv", "Root", pcdrv_root.c_str());
+
+  si.SetBoolValue("Debug", "PCSXExpansionRegion", pcsx_expansion_region_enable);
 }
 
 bool Settings::TextureReplacementSettings::Configuration::operator==(const Configuration& rhs) const
@@ -1160,6 +1164,7 @@ void Settings::ApplySettingRestrictions()
     rewind_enable = false;
     pio_device_type = PIODeviceType::None;
     pcdrv_enable = false;
+    pcsx_expansion_region_enable = false;
     dma_max_slice_ticks = DEFAULT_DMA_MAX_SLICE_TICKS;
     dma_halt_ticks = DEFAULT_DMA_HALT_TICKS;
     gpu_fifo_size = DEFAULT_GPU_FIFO_SIZE;
diff --git a/src/core/settings.h b/src/core/settings.h
index 4d8e9c401..279a6ed6a 100644
--- a/src/core/settings.h
+++ b/src/core/settings.h
@@ -301,6 +301,7 @@ struct Settings : public GPUSettings
 
   bool pcdrv_enable : 1 = false;
   bool pcdrv_enable_writes : 1 = false;
+  bool pcsx_expansion_region_enable : 1 = false;
 
   bool pio_switch_active : 1 = true;
   bool pio_flash_write_enable : 1 = false;
diff --git a/src/core/system.cpp b/src/core/system.cpp
index ee326c67a..3854e0cac 100644
--- a/src/core/system.cpp
+++ b/src/core/system.cpp
@@ -4878,6 +4878,8 @@ void System::WarnAboutUnsafeSettings()
       append(TRANSLATE_SV("System", "PIO device removed."));
     if (g_settings.pcdrv_enable)
       append(TRANSLATE_SV("System", "PCDrv disabled."));
+    if (g_settings.pcsx_expansion_region_enable)
+      append(TRANSLATE_SV("System", "PCSX Expansion Region disabled."));
     if (g_settings.bios_patch_fast_boot)
       append(TRANSLATE_SV("System", "Fast boot disabled."));
 
diff --git a/src/duckstation-qt/debuggingsettingswidget.cpp b/src/duckstation-qt/debuggingsettingswidget.cpp
index 832b918c4..c0da05321 100644
--- a/src/duckstation-qt/debuggingsettingswidget.cpp
+++ b/src/duckstation-qt/debuggingsettingswidget.cpp
@@ -247,6 +247,8 @@ void DebuggingSettingsWidget::addTweakOptions()
   addIntRangeTweakOption(m_dialog, m_ui.tweakOptionTable, tr("GDB Server Port"), "Debug", "GDBServerPort", 1, 65535,
                          Settings::DEFAULT_GDB_SERVER_PORT);
 
+  addBooleanTweakOption(m_dialog, m_ui.tweakOptionTable, tr("Enable PCSX Expansion Region"), "Debug",
+                        "PCSXExpansionRegion", false);
   addBooleanTweakOption(m_dialog, m_ui.tweakOptionTable, tr("Export Shared Memory"), "Hacks", "ExportSharedMemory",
                         false);
   addBooleanTweakOption(m_dialog, m_ui.tweakOptionTable, tr("Redirect SIO to TTY"), "SIO", "RedirectToTTY", false);
@@ -294,10 +296,11 @@ void DebuggingSettingsWidget::onResetToDefaultClicked()
     setBooleanTweakOption(m_ui.tweakOptionTable, i++, false);                // Enable GDB Server
     setIntRangeTweakOption(m_ui.tweakOptionTable, i++, Settings::DEFAULT_GDB_SERVER_PORT); // GDB Server Port
     setBooleanTweakOption(m_ui.tweakOptionTable, i++, false);                              // Export Shared Memory
-    setBooleanTweakOption(m_ui.tweakOptionTable, i++, false);                              // Redirect SIO to TTY
-    setBooleanTweakOption(m_ui.tweakOptionTable, i++, false);                              // Enable PCDRV
-    setBooleanTweakOption(m_ui.tweakOptionTable, i++, false);                              // Enable PCDRV Writes
-    setDirectoryOption(m_ui.tweakOptionTable, i++, "");                                    // PCDrv Root Directory
+    setBooleanTweakOption(m_ui.tweakOptionTable, i++, false); // Enable PCSX Expansion Region
+    setBooleanTweakOption(m_ui.tweakOptionTable, i++, false); // Redirect SIO to TTY
+    setBooleanTweakOption(m_ui.tweakOptionTable, i++, false); // Enable PCDRV
+    setBooleanTweakOption(m_ui.tweakOptionTable, i++, false); // Enable PCDRV Writes
+    setDirectoryOption(m_ui.tweakOptionTable, i++, "");       // PCDrv Root Directory
 
     return;
   }
@@ -330,6 +333,7 @@ void DebuggingSettingsWidget::onResetToDefaultClicked()
   sif->DeleteValue("CDROM", "AllowBootingWithoutSBIFile");
   sif->DeleteValue("Debug", "EnableGDBServer");
   sif->DeleteValue("Debug", "GDBServerPort");
+  sif->DeleteValue("Debug", "PCSXExpansionRegion");
   sif->DeleteValue("SIO", "RedirectToTTY");
   sif->DeleteValue("PCDrv", "Enabled");
   sif->DeleteValue("PCDrv", "EnableWrites");